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More than 1 + 2 in mRNA decapping

Nature Structural & Molecular Biology volume 13, pages 7–9 (2006)Cite this article

Decapping of messenger RNA was thought to involve a complex of only Dcp1 and Dcp2, but new data suggest that a larger multisubunit decapping complex exists in mammals. The larger complex includes a protein that facilitates the association of the two Dcp proteins and can be recruited by specific factors that promote mRNA decay.

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Figure 1: Model of potential Dcp2 decapping complexes.
Figure 2: Activation of ARE-containing mRNA decay by TTP.

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Authors and Affiliations

  1. Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, 08854-8082, New Jersey, USA

    Sophie Bail & Megerditch Kiledjian

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  1. Sophie Bail
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  2. Megerditch Kiledjian
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Bail, S., Kiledjian, M. More than 1 + 2 in mRNA decapping. Nat Struct Mol Biol 13, 7–9 (2006). https://doi.org/10.1038/nsmb0106-7

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