The structure of TAG, a DNA repair enzyme, reveals how evolutionary changes in the sequence of a conserved scaffold may enrich the mechanistic diversity of the DNA HhH glycosylase superfamily through a unique coupling of catalysis to substrate selectivity.
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Acknowledgements
We thank J.T. Stivers for providing the TAG coordinates, and A. Farooq for helping with figure preparation.
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Yan, K., Zhou, MM. TAGging the target for damage control. Nat Struct Mol Biol 9, 638–640 (2002). https://doi.org/10.1038/nsb0902-638
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DOI: https://doi.org/10.1038/nsb0902-638
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