Topical anesthetics are moderately effective treatments for premature ejaculation. In a 12 week, double-blind RCT, a metered-dose aerosol spray containing lidocaine and prilocaine (PSD502) showed a 6.3-fold increase in intravaginal ejaculatory latency times, improved all patient-reported outcomes and had no serious adverse effects.
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McMahon, C. Anesthetic spray improves premature ejaculation. Nat Rev Urol 6, 472–473 (2009). https://doi.org/10.1038/nrurol.2009.144
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DOI: https://doi.org/10.1038/nrurol.2009.144
