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Genetics meets epigenetics: HDACs and Wnt signaling in myelin development and regeneration

A study shows that the histone deacetylases HDAC1 and HDAC2 stimulate oligodendrocyte differentiation by antagonizing the inhibitory action of Wnt signaling, linking genetic and epigenetic control of oligodendrocyte development.

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Figure 1: The role of HDACs in oligodendrocyte lineage progression and terminal differentiation.

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Correspondence to William D Richardson.

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Li, H., Richardson, W. Genetics meets epigenetics: HDACs and Wnt signaling in myelin development and regeneration. Nat Neurosci 12, 815–817 (2009). https://doi.org/10.1038/nn0709-815

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