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Nature Neuroscience 10, 397 - 399 (2007)
doi:10.1038/nn0407-397
GABA receptors make teens resistant to input
Margaret M McCarthy1
- The author is in the Departments of Physiology and Psychiatry, University of Maryland Baltimore School of Medicine, 655 W. Baltimore St., Baltimore, Maryland 21201, USA. e-mail: mmccarth@umaryland.edu
Abstract
Neurosteroids generally reduce anxiety, but a new paper shows that they promote anxiety in female mice around puberty via the selective desensitization of extrasynaptic GABAA receptors made up of 
4
2
subunits. This change increases input resistance and excitation of hippocampal pyramidal neurons, thus promoting anxiety.
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RESEARCH
Reversal of neurosteroid effects at α4β2δ GABA A receptors triggers anxiety at pubertyNature Neuroscience Article (01 Apr 2007)