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Prion disease: bridging the spleen-nerve gap

Nature Medicine volume 9, pages 1463–1464 (2003)Cite this article

Infection of tissues outside the nervous system occurs in a number of prion diseases, but sporadic Creutzfeldt-Jakob disease in humans has not been considered one of them. A clinical study of Swiss patients with sporadic disease reconsiders this assumption, and a second study examines the spread of infection between follicular dendritic cells and nerves.

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Figure 1: Proximity breeds infectivity.

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Authors and Affiliations

  1. Institute for Animal Health, Ogston Building, West Mains Road, Edinburgh, EH9 3JF, UK

    Neil A Mabbott & Moira E Bruce

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  1. Neil A Mabbott
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  2. Moira E Bruce
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Mabbott, N., Bruce, M. Prion disease: bridging the spleen-nerve gap. Nat Med 9, 1463–1464 (2003). https://doi.org/10.1038/nm1203-1463

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