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Epilepsy and the too-well-connected brain

Nature Medicine volume 3, pages 957–958 (1997)Cite this article

New excitatory brain circuitry induced by injury: a leading pathophysiology or an also-ran in post-traumatic epilepsy ? (pages 990–996)

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References

  1. Dichter, M. & Spencer, W.A. Penicillin-induced interictal discharges from the cat hippocampus. II. Mechanisms underlying origin and restriction. J. Neurophysiol. 32, 663–687 (1969).

    Article  CAS  Google Scholar 

  2. Traub, R.D. & Wong, R.K. Cellular mechanism of neuronal synchronization in epilepsy. Science 216, 745–747 (1982).

    Article  CAS  Google Scholar 

  3. McKinney, R.A., Debanne, D., Gahwiler, B.H. & Thompson, S.M. Lesion-induced axonal sprouting and hyperexcitability in the hippocampus in vitro: implications for the genesis of post-traumatic epilepsy. Nature Med. 3, 990–996 (1997).

    Article  CAS  Google Scholar 

  4. Ramon y Cajal, S. Study of traumatic degeneration in the cerebral cortex. In Degeneration and regeneration of the nervous system. (Ed. May, R.M.) 656–692 (Oxford University Press, London, 1928).

    Google Scholar 

  5. Salin, P., Tseng, G.F., Hoffman, S., Parada, I. & Prince, D.A. Axonal sprouting in layer V pyramidal neurons of chronically injured cerebral cortex. J. Neurosci. 15, 8234–8245 (1995).

    Article  CAS  Google Scholar 

  6. Tauck, D.L. & Nadler, J.V. Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid treated rats. J. Neurosci. 5, 1016–1022 (1985).

    Article  CAS  Google Scholar 

  7. Perez, Y., Morin, F., Beaulieu, C. & Lacaille, J.C. Axonal sprouting of CA1 pyramidal cells in hyper-excitable hippocampal slices of kainate-treated rats. Eur. J. Neurosci. 8, 736–748 (1996).

    Article  CAS  Google Scholar 

  8. Longo, B.M. & Mello, L.E.A.M. Blockade of pilo-carpine-or kainate-induced mossy fiber sprouting by cycloheximide does not prevent subsequent epileptogenesis in rats. Neurosci. Lett. 226, 163–166 (1997).

    Article  CAS  Google Scholar 

  9. Qiao, X. & Noebels, J.L. Developmental analysis of hippocampal mossy fiber outgrowth in a mutant mouse with inherited spike-wave seizures. J. Neurosci. 13, 4622–4635 (1993).

    Article  CAS  Google Scholar 

  10. Coulter, D.A. et al. Brain injury-induced enhanced limbic epileptogenesis: Anatomical and physiological parallels to an animal model of temporal lobe epilepsy. Epilepsy Res. 26, 81–91 (1996).

    Article  CAS  Google Scholar 

  11. Amaral, D.G., Ishizuka, N. & Claiborne, B., Neurons, numbers and the hippocampal network. Prog. Brain Res. 83, 1–11 (1990).

    Article  CAS  Google Scholar 

  12. MacVicar, B.A. & Dudek, F.E. Local synaptic circuits in rat hippocampus: interactions between pyramidal cells. Brain Res. 184, 220–223 (1980).

    Article  CAS  Google Scholar 

  13. Coltman, B.W., Earley, E.M., Shahar, A., Dudek, F.E. & Ide, C.F. Factors influencing mossy fiber collateral sprouting in organotypic slice cultures of neonatal mouse hippocampus. J. Comp. Neurol. 362, 209–222 (1995).

    Article  CAS  Google Scholar 

Download references

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  1. Department of Neurology and Neurological Sciences, Standford University School of Medicine, Standford, California, 94305, USA

    David A. Prince

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  1. David A. Prince
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Prince, D. Epilepsy and the too-well-connected brain. Nat Med 3, 957–958 (1997). https://doi.org/10.1038/nm0997-957

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