Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

HOX gene mutations — the wait is over

Nature Medicine volume 2, pages 748–749 (1996)Cite this article

Mutations in a human HOX gene have been found in patients with the limb deformity, synpolydactyly.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Lewis, E.B. A gene complex controlling segmentation in Drosophila . Nature 276, 565–570 (1978).

    Article  CAS  Google Scholar 

  2. Muragaki, Y., Mundlos, S., Upton, J. & Olsen, B.R. Altered growth and branching patterns in synpolydactyly caused by mutations in HOXD13 . Science 272, 548–550 (1996).

    Article  CAS  Google Scholar 

  3. Jabs, E.W. et al. A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant cranio-synostosis. Cell 75, 443–450 (1993).

    Article  CAS  Google Scholar 

  4. Brunelli, S. et al. Germline mutations in the homeobox gene EMX2 in patients with severe schizencephaly. Nature. Gen. 12, 94–96 (1996).

    Article  CAS  Google Scholar 

  5. Izpisua-Belmonte, J.C., Tickle, C., Dollé, P., Wolpert, L. & Duboule, D. Expression of the homeobox Hox-4 genes and the specification of position in the chick limb bud. Nature 350, 585–631 (1991).

    Article  CAS  Google Scholar 

  6. Dollé, P. et al. Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell 75, 431–441 (1993).

    Article  Google Scholar 

  7. Catron, K.M., Wang, H., Hu, G., Shen, M.M. & Abate-Shen, C. Comparison of MSX-1 and MSX-2 suggests a molecular basis for functional redundancy. Mech. Dev. 55, 185–199 (1996).

    Article  CAS  Google Scholar 

  8. Uwanogho, D. et al. Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an interactive role in neuronal development. Mech. Dev. 49, 23–36 (1995).

    Article  CAS  Google Scholar 

  9. Mortlock, D.P., Post, L.C. & Innis, J.W. The molecular basis of Hypodactyly (Hd): A deletion in Hoxa-13 leads to arrest of digital arch formation. Nature Genet. 13, 284–289 (1996).

    Article  CAS  Google Scholar 

  10. Yokouchi, Y. et al. Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds. Genes Dev. 9, 2509–2522 (1995).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Craniofacial Development, Guy's Hospital, United Medical and Dental Schools London, SE1 9RT, UK

    Paul Sharpe

Authors
  1. Paul Sharpe
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sharpe, P. HOX gene mutations — the wait is over. Nat Med 2, 748–749 (1996). https://doi.org/10.1038/nm0796-748

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0796-748

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing