Electrical stimulation of the globus pallidus alleviates the symptoms of Parkinson's disease by increasing activity of brain areas involved in movement (pages 671–674).
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References
Laitinen, L.V., Bergenheim, A.T. & Hariz, M.I. Leksell's posteroventral pallidotomy in the treatment of Parkinson's disease. J. Neurosurgery 76, 53–61 (1992).
Dogali, M. et al. Stereotactic ventral pallidotomy for Parkinson's disease. Neurology 45, 753–761 (1995).
Lozano, A.M. et al. Effect of CPi pallidotomy on motor function in Parkinson's disease. Lancet 346, 1383–1387 (1995).
Baron, M.S., et al. Treatment of advanced Parkinson's disease by posterior GPi pallidotomy: 1-year results of a pilot study. Annals of Neurology 40, 355–356 (1996).
Davis, K.D. et al. Globus pallidus stimulation activates the cortical motor system during alleviation of parkinsonian symptoms. Nature Med. 3, 671–674 (1997).
Winstein, C.J., Grafton, S.T. & Pohl, P.S. Motor task difficulty and brain activity: an investigation of goal-directed reciprocal aiming using positron emission tomography (PET). J. Neurophysiol. 77, 1581–1594 (1996).
Wichmann, T. & DeLong, M.R. Functional and pathophysiological models of the basal ganglia. Current Opinions in Neurobiology 6, 751–758 (1996).
Jenkins, I.H. et al. Impaired activation of the supplementary motor area in Parkinson's disease is reversed when akinesia is treated with apomorphine. Annals of Neurology 32, 749–757 (1992).
Playford, E.D. et al. Impaired mesial frontal and putamen activation in Parkinson's disease: a positron emission tomography study. Annals of Neurology 32, 151–161 (1992).
Ceballos-Baumann, A.O. et al. Restoration of thalamocortical activity after posteroventral pallidotomy in Parkinson's disease. Lancet 344, 814 (1994).
Grafton, S.T., Waters, C., Sutton, J., Lew, M.F. & Couldwell, W. Pallidotomy increases activity of motor association cortex in Parkinson's disease: a PET study. Annals of Neurology 37, 776–783 (1995).
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Grafton, S., DeLong, M. Tracing the brain's circuitry with functional imaging. Nat Med 3, 602–603 (1997). https://doi.org/10.1038/nm0697-602
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DOI: https://doi.org/10.1038/nm0697-602
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