Melanoma may be promoted by low oxygen conditions in the skin, which turn on the oxygen-response regulator HIF-1. HIF-1 seems to act in concert with well-established oncoproteins to promote tumorigenesis—a process that responds to the drug rapamycin.
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Adams, A., Chudnovsky, Y. & Khavari, P. Oxygen deprivation provokes melanoma. Nat Med 12, 168–169 (2006). https://doi.org/10.1038/nm0206-168
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DOI: https://doi.org/10.1038/nm0206-168
