Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Predicting the future of breast cancer

Two new studies suggest that tests based on Cyclin E or microarray analysis have the potential to outperform conventional criteria predicting the outcome of breast cancer.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Prognostic performance of microarray and cyclin E analyses.

Reprinted with permission from NEJM

References

  1. Keyomarsi, K. et al. Cyclin E and survival in patients with breast cancer. N. Engl. J. Med. 347, 1566–1575 (2002).

    Article  CAS  Google Scholar 

  2. Van de Vijver, M.J. et al. A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med. 34, 1999–2009 (2002).

    Article  Google Scholar 

  3. van't Veer, L.J. et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415, 530–536 (2002).

    Article  CAS  Google Scholar 

  4. Bernards, R. & Weinberg, R.A. A progression puzzle. Nature 418, 823 (2002).

  5. Porter, D.C. et al. Tumor-specific proteolytic processing of cyclin E generates hyperactive lower-molecular-weight forms. Mol. Cell. Biol. 21, 6254–6269 (2001).

    Article  CAS  Google Scholar 

  6. Strohmaier, H. et al. Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 413, 316–322 (2001).

    Article  CAS  Google Scholar 

  7. Spruck, C.H., Won, K.A. & Reed, S.I. Deregulated cyclin E induces chromosome instability. Nature 401, 297–300 (1999).

    Article  CAS  Google Scholar 

  8. Bermejo, R., Vilaboa, N. & Cales, C. Regulation of CDC6, Geminin, and CDT1 in human cells that undergo polyploidization. Mol. Biol. Cell 13, 3989–4000 (2002).

    Article  CAS  Google Scholar 

  9. Payton, M. & Coats, S. Cyclin E2, the cycle continues. Int. J. Biochem. Cell. Biol. 34, 315–320 (2002).

    Article  CAS  Google Scholar 

  10. Clark G. In Diseases of the Breast (eds. Harris, J., Lippman, M., Morrow, M. & Hellman, S.) 461–485 (Lippincott-Raven Publishers, Philadelphia, 1996).

    Google Scholar 

  11. Sjostrom, J. Predictive factors for response to chemotherapy in advanced breast cancer. Acta Oncol. 41, 334–345 (2002).

    Article  CAS  Google Scholar 

  12. Perou, C.M. et al. Molecular portraits of human breast tumours. Nature 406, 747–752 (2000).

    Article  CAS  Google Scholar 

  13. Gruvberger, S. et al. Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns. Cancer Res. 61, 5979–5984 (2001).

    CAS  PubMed  Google Scholar 

  14. Loden, M. et al. The cyclin D1 high and cyclin E high subgroups of breast cancer: Separate pathways in tumorigenesis based on pattern of genetic aberrations and inactivation of the pRb node. Oncogene 21, 4680–4690 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Åke Borg.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Borg, Å., Fernö, M. & Peterson, C. Predicting the future of breast cancer. Nat Med 9, 16–18 (2003). https://doi.org/10.1038/nm0103-16

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0103-16

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing