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Tailoring the genome: the power of genetic approaches

Nature Genetics volume 33, pages 276–284 (2003)Cite this article

Abstract

In the last century, genetics has developed into one of the most powerful tools for addressing basic questions concerning inheritance, development, individual and social operations and death. Here we summarize the current approaches to these questions in four of the most advanced models organisms: Saccharomyces cerevisiae (yeast), Caenorhabditis elegans (worm), Drosophila melanogaster (fly) and Mus musculus (mouse). The genomes of each of these four models have been sequenced, and all have well developed methods of efficient genetic manipulations.

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Figure 1: Schematics of typical recessive chemical mutagenesis screens in the model systems discussed: yeast, worm, fly, mouse and ES cell.

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Authors and Affiliations

  1. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, M5G 1X5, Ontario, Canada

    Andras Nagy

  2. Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada

    Andras Nagy

  3. Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Ave., Boston, 02115, Massachusetts, USA

    Norbert Perrimon

  4. Department of Biological Chemistry, Medical Sciences I, D240, College of Medicine, University of California, Irvine, 92697-1700, California, USA

    Suzanne Sandmeyer

  5. Hubrecht Laboratory, Center for Biomedical Genetics, Uppsalalaan 8, Utrecht, 3584 CT, The Netherlands

    Ronald Plasterk

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Nagy, A., Perrimon, N., Sandmeyer, S. et al. Tailoring the genome: the power of genetic approaches. Nat Genet 33 (Suppl 3), 276–284 (2003). https://doi.org/10.1038/ng1115

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