Abstract
Junction fragments from the constitutional t(11;22)(q23;q11) translocation have previously been cloned and sequenced. Here we report a high incidence of translocation-specific PCR products in sperm DNA from normal individuals. Somatic DNA from these and other normal individuals or from people with chromosomal breakage syndromes do not yield PCR junction fragments, indicating that this translocation originates during meiosis.
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Acknowledgements
We would like to thank H. Kono, L. Mitchell, R. Wilson and C. Felix for helpful discussions. These studies were supported in part by CA39926 (BSE), HD26979 from the NIH, and funds from the Charles E.H. Upham chair (BSE).
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Kurahashi, H., Emanuel, B. Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males. Nat Genet 29, 139–140 (2001). https://doi.org/10.1038/ng1001-139
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DOI: https://doi.org/10.1038/ng1001-139
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