Comparative studies of nematode development provide a powerful framework for investigating the evolution of developmental mechanisms. A recent report also demonstrates how comparative work can inform our understanding of basic developmental signaling pathways. In particular, investigation of the differences in vulva development between Caenorhabditis elegans and Pristionchus pacificus has clarified the molecular relationship between an epidermal growth factor–Ras–MAP kinase signaling pathway and downstream Hox transcription factor activity.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Grandien, K. & Sommer, R.J. Genes Dev. 15, 2161–2172 (2001).
Clark, S.G., Chisholm, A.D. & Horvitz, H.R. Cell 74, 43–55 (1993).
Hill, R.J. & Sternberg, P.W. Nature 358, 470–476 (1992).
Kornfeld, K. Trends Genet. 13, 55–61 (1997).
Sommer, R. J. & Sternberg, P.W. Curr. Biol. 6, 52–59 (1996).
Sigrist, C.B. & Sommer R.J. Dev. Genes Evol. 209, 451–459 (1999).
Clandinin, T.R., Katz, W.S. & Sternberg, P.W. Dev. Biol. 182, 150–161 (1997).
Maloof, J.N. & Kenyon, C. Development 125, 181–190 (1998).
Eisenman, D.M., Maloof, J.N., Simske, J.S., Kenyon, C. & Kim S.K. Development 125, 3667–3680 (1998).
Eizinger, A. & Sommer, R.J. Science 278, 452–455 (1997).
Sommer, R.J., Eizinger, A., Lee K.Z., Jungblut, B., Bubeck, A. & Schlak, I. Development 125, 3865–3873 (1998).
Tautz, D. Curr. Opin. Genet. Dev. 10, 575–579 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Chamberlin, H. The adaptable lin-39. Nat Genet 29, 106–107 (2001). https://doi.org/10.1038/ng1001-106
Issue Date:
DOI: https://doi.org/10.1038/ng1001-106