Gene expression microarray data on each individual in a pedigree or from an experimental cross enable the identification of the genetic determinants of variation in gene expression. Three new studies apply this approach to rodent recombinant inbred lines and provide new insights into the nature of variation in gene expression and its connection to disease.
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References
Jansen, R.C. & Nap, J.P. Trends Genet. 17, 388–391 (2001).
Chesler, E.J. et al. Nat. Genet. 37, 233–242 (2005).
Bystrykh, L. et al. Nat. Genet. 37, 225–232 (2005).
Hübner, N. et al. Nat. Genet. 37, 243–253 (2005).
Brem, R.B. et al. Science 296, 752–755 (2002).
Yvert, G. et al. Nat. Genet. 35, 57–64 (2003).
Schadt, E.E. et al. Nature 422, 297–302 (2003).
Cheung, V.G. et al. Nat. Genet. 33, 422–425 (2003).
Morley, M. et al. Nature 430, 743–747 (2004).
Silver, L.M. Mouse Genetics: Concepts and Applications (Oxford University Press, New York, 1995).
Belknap, J.K. et al. Behav. Genet. 26, 149–160 (1996).
The Complex Trait Consortium. Nat. Genet. 36, 1133–1137 (2004).
Korstanje, R. & Paigen, B. Nat. Genet. 31, 235–236 (2002).
Wayne, M.L. & McIntyre, L.M. Proc. Natl. Acad. Sci. USA 99, 14903–14906 (2002).
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Broman, K. Mapping expression in randomized rodent genomes. Nat Genet 37, 209–210 (2005). https://doi.org/10.1038/ng0305-209
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DOI: https://doi.org/10.1038/ng0305-209
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