The spatially and temporally coordinated interaction between migratory cardiac precursors, endothelial cells and myogenic precursors leads to the formation of the highly differentiated cell lineages in the heart. In a new study, conditional mouse mutants are used to show that Nf1 signaling in cardiac endothelium is essential for proper heart formation.
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Ruiz-Lozano, P., Chien, K. Cre-constructing the heart. Nat Genet 33, 8–9 (2003). https://doi.org/10.1038/ng0103-8
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DOI: https://doi.org/10.1038/ng0103-8
