A mouse model for familial adenomatous polyposis has been used to distinguish between possible mechanisms leading to loss of function of the Apc tumor-suppressor gene. Somatic recombination rather than chromosome loss associated with genetic instability is the primary cause of these cancers. Moreover, the data suggest that interphase nuclear architecture is a key factor in facilitating this process.
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Tischfield, J., Shao, C. Somatic recombination redux. Nat Genet 33, 5–6 (2003). https://doi.org/10.1038/ng0103-5
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DOI: https://doi.org/10.1038/ng0103-5
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