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Direct brain infusion of glial cell line derived neurotrophic factor in Parkinson disease

Brain catheter feeds beleaguered cells; taking iron out protects them.

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References

  1. Gill, S.S. et al. Direct brain infusion of glial cell line derived neurotrophic factor in Parkinson disease. Nature Medicine, published online, doi:10.1038/nm850 (2003).

  2. Picconi, B. et al. Loss of bi-directional striatal synaptic plasticity in L-DOPA-induced dyskinesia. Nature Neuroscience, published online, doi:10.1038/nn1040 (2003).

  3. Kaur, D. et al. Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxcity in vivo: a novel therapy for Parkinson's disease. Neuron, 37, 923 - 933, (2003).

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University of Rome

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Direct brain infusion of glial cell line derived neurotrophic factor in Parkinson disease. Nature (2003). https://doi.org/10.1038/news030324-12

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