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Transcriptional activation by small RNA duplexes

Nature Chemical Biology volume 3, pages 136–137 (2007)Cite this article

Short double-stranded RNA duplexes are the triggers for post-transcriptional gene silencing and can also induce epigenetic silencing of genes at the level of transcription. A surprising new finding is that short RNA duplexes targeted to promoter regions can also mediate potent enhancement of transcription.

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Figure 1: Hypothetical model for agRNA-triggered RNAa.

Kim Caesar

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Authors and Affiliations

  1. John J. Rossi is in the Division of Molecular Biology, Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA. jrossi@bricoh.edu,

    John J Rossi

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  1. John J Rossi
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Rossi, J. Transcriptional activation by small RNA duplexes. Nat Chem Biol 3, 136–137 (2007). https://doi.org/10.1038/nchembio0307-136

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