After years of waiting, the road map for the path of the mRNA on the ribosome with its associated tRNAs has been completed. In contrast to the amino-acid-coding nucleotides of the body of the mRNA, the Shine-Delgarno region appears to take an unexpected turn on the surface of the 30S subunit in the transition from the initiation complex to the postinitiation complex.
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Kim Caesar
References
Makowski, I. et al. J. Mol. Biol. 193, 819–822 (1987).
Ban, N. et al. Nature 400, 841–847 (1999).
Wimberly, B.T. et al. Nature 407, 327–339 (2000).
Yusupov, M.M. et al. Science 292, 883–896 (2001).
Agrawal, R.K. et al. J. Cell Biol. 150, 447–460 (2000).
Yusupova, G. et al. Nature 444, 391–394 (2006).
Ogle, J.M. et al. Cell 111, 721–732 (2002).
McCutcheon, J.P. et al. Proc. Natl. Acad. Sci. USA 96, 4301–4306 (1999).
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Merrick, W. Are we there yet?. Nat Chem Biol 3, 19–20 (2007). https://doi.org/10.1038/nchembio0107-19
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DOI: https://doi.org/10.1038/nchembio0107-19
