Drug-resistant bacteria are a growing challenge to world health, and new approaches to antibiotic development are needed. Riboswitches, regulatory elements of mRNA, are shown to be a potential new target for antibiotic drugs.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Riboswitch Detection Using Profile Hidden Markov Models
BMC Bioinformatics Open Access 08 October 2009
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Lindsay, J.A. & Holden, M.T. Funct. Integr. Genomics 6, 186–202 (2006).
Blount, K.F., Wang, J.X., Lim, J., Sudarsan, N. & Breaker, R.R. Nat. Chem. Biol. 3, 44–49 (2007)
Tucker, B.J. & Breaker, R.R. Curr. Opin. Struct. Biol. 15, 342–348 (2005).
Roth, A., Nahvi, A., Lee, M., Jona, I. & Breaker, RR. RNA 12, 607–619 (2006).
Vitreschak, A.G., Rodionov, D.A., Mironov, A.A. & Gelfand, M.S. Trends Genet. 20, 44–50 (2004).
Cromie, M.J., Shi, Y., Latifi, T. & Groisman, E.A. Cell 125, 71–84 (2006).
Sudarsan, N., Cohen-Chalamish, S., Nakamura, S., Emilsson, G.M. & Breaker, R.R. Chem. Biol. 12, 1325–1335 (2005).
Sudarsan, N., Wickiser, J.K., Nakamura, S., Ebert, M.S. & Breaker, RR. Genes Dev. 17, 2688–2697 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lea, C., Piccirilli, J. 'Turning on' riboswitches to their antibacterial potential. Nat Chem Biol 3, 16–17 (2007). https://doi.org/10.1038/nchembio0107-16
Issue Date:
DOI: https://doi.org/10.1038/nchembio0107-16
This article is cited by
-
Riboswitch Detection Using Profile Hidden Markov Models
BMC Bioinformatics (2009)
-
Modeling the noncovalent interactions at the metabolite binding site in purine riboswitches
Journal of Molecular Modeling (2009)