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Ahead of the curve: mitochondrial fusion and phospholipase D

Nature Cell Biology volume 8, pages 1215–1217 (2006)Cite this article

A new study has identified a novel phospholipase D (PLD) that is located in the mitochondrial outer membrane and is required for organelle fusion. As PLD-catalysed production of fusogenic lipids is critical for many examples of membrane fusion (such as those mediated by SNAREs), this startling finding raises the possibility that mitochondria use a mechanism common to other cellular fusion events.

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Figure 1: A schematic representation of a model for MitoPLD in mitochondrial fusion.

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Authors and Affiliations

  1. Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, 21205, MD, USA

    Robert E. Jensen & Hiromi Sesaki

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  1. Robert E. Jensen
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  2. Hiromi Sesaki
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Jensen, R., Sesaki, H. Ahead of the curve: mitochondrial fusion and phospholipase D. Nat Cell Biol 8, 1215–1217 (2006). https://doi.org/10.1038/ncb1106-1215

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