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Nuclear transfer: Epigenetics pays a visit

Nature Cell Biology volume 6, pages 920–922 (2004)Cite this article

Nuclear transfer, an essential step in animal cloning, results in the reprogramming of nuclei from a restricted, somatic cell programme to the totipotent pattern typical of the early embryo. A key variable in the success of cloning could be the resetting of the epigenetic status of the donor nucleus, including patterns of DNA methylation. New experiments offer insights into this poorly understood process.

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Figure 1: The figure depicts one potential model of the events occurring during nuclear transfer.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University, Whitehead Building Room 142, 615 Michael Street, Atlanta, GA, USA

    Naoyuki Fujita & Paul A. Wade

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  1. Naoyuki Fujita
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  2. Paul A. Wade
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Fujita, N., Wade, P. Nuclear transfer: Epigenetics pays a visit. Nat Cell Biol 6, 920–922 (2004). https://doi.org/10.1038/ncb1004-920

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