Transcriptional cycling of activated glucocorticoid receptor (GR) and ultradian glucocorticoid secretion are well established processes. Ultradian hormone release is now shown to result in pulsatile gene transcription through dynamic exchange of GR with the target-gene promoter and GR cycling through the chaperone machinery.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
The stress of starvation: glucocorticoid restraint of beta cell development
Diabetologia Open Access 12 November 2010
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Lightman, S. L. et al. Eur. J. Pharmacol. 583, 255–262 (2008).
Stavreva, D. A. et al. Nature Cell Biol., 11, 1093–1102 (2009).
Newton, R. Thorax 55, 603–613 (2000).
Rhen, T. & Cidlowski, J. A. N. Engl. J. Med. 353, 1711–1723 (2005).
McNally, J. G. et al. Science 287, 1262–1265 (2000).
Stavreva, D. A. et al. Mol. Cell. Biol. 24, 2682–2697 (2004).
Sun, L., Yang, G., Zaidi, M. & Iqbal, J. Biochem. Biophys. Res. Commun. 371, 900–905 (2008).
Métivier, R., Reid, G. & Gannon, F. EMBO Rep. 7, 161–167 (2006).
Freeman, B. C. & Yamamoto, K. R. Science 296, 2232–2235 (2002).
Freeman, B. C. & Yamamoto, K. R. Trends Biochem. Sci. 26, 285–290 (2001).
Biddie, S. C. & Hager, G. L. Stress 12, 193–205 (2009).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Desvergne, B., Héligon, C. Steroid hormone pulsing drives cyclic gene expression. Nat Cell Biol 11, 1051–1053 (2009). https://doi.org/10.1038/ncb0909-1051
Issue Date:
DOI: https://doi.org/10.1038/ncb0909-1051
This article is cited by
-
The stress of starvation: glucocorticoid restraint of beta cell development
Diabetologia (2011)