1. In-Hyun Park is in the Division of Pediatric Hematology/Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA.
2. George Q. Daley is in the Division of Pediatric Hematology/Oncology, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA, Division of Hematology, Brigham and Women's Hospital, Boston, MA 02115, USA, and Harvard Stem Cell Institute, Boston, MA 02115, USA. e-mail: George.Daley@childrens.harvard.edu

Abstract

Last year it was reported that a cocktail of four transcription factors — encoded by Oct4, Sox2, Myc and Klf4 — can partly reprogramme mouse somatic cells to an embryonic state, a process that reawakens silenced segments of the genome and restores pluripotency to the somatic cell nucleus. Three groups have now modified this method to generate fully reprogrammed cells that closely resemble embryonic stem cells.

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