Phosphoinositide 3-kinases (PI(3)Ks) are mainly known for their lipid kinase activity in various cellular functions; however, PI(3)Ks also have protein kinase activity. Non-muscle tropomyosin has been identified as a novel protein target for PI(3)Kγ. Phosphorylation of tropomyosin is required for β-adrenergic receptor internalization, providing new insight into PI(3)K function during clathrin-mediated endocytosis.
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Backer, J. Substrate specificity: PI(3)Kγ has it both ways. Nat Cell Biol 7, 773–774 (2005). https://doi.org/10.1038/ncb0805-773
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DOI: https://doi.org/10.1038/ncb0805-773
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