APC/CCdh1 controls the G0 and G1 phases of the cell cycle. Using a conditional knockout of the Cdh1 coding gene Fizzy-related (Fzr), a new study demonstrates that Cdh1 is essential for viability and that it functions as a tumour suppressor by preventing genomic instability.
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Skaar, J., Pagano, M. Cdh1: a master G0/G1 regulator. Nat Cell Biol 10, 755–757 (2008). https://doi.org/10.1038/ncb0708-755
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DOI: https://doi.org/10.1038/ncb0708-755
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