Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Towards cell therapy for diabetes

A protocol based on pancreatic development efficiently converts human embryonic stem cells into insulin-producing cells.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Directed differentiation of hES cells to insulin-producing cells by mimicking embryonic development, as described in ref. 3.

Katie Ris

References

  1. Bonner-Weir, S. & Weir, G.C. Nat. Biotechnol. 23, 857–861 (2005).

    Article  CAS  Google Scholar 

  2. Shapiro, A.M. et al. N. Engl. J. Med. 355, 1318–1330 (2006).

    Article  CAS  Google Scholar 

  3. D'Amour, K.A. et al. Nat. Biotechnol. 24, 1392–1401 (2006).

    Article  CAS  Google Scholar 

  4. D'Amour, K.A. et al. Nat. Biotechnol. 23, 1534–1541 (2005).

    Article  CAS  Google Scholar 

  5. Lewis, S.L. & Tam, P.P. Dev. Dyn. 235, 2315–2329 (2006).

    Article  Google Scholar 

  6. Collombat, P., Hecksher-Sorensen, J., Serup, P. & Mansouri, A. Mech. Dev. 123, 501–512 (2006).

    Article  CAS  Google Scholar 

  7. Polak, M., Bouchareb-Banaei, L., Scharfmann, R. & Czernichow, P. Diabetes 49, 225–232 (2000).

    Article  CAS  Google Scholar 

  8. Nishimura, W. et al. Dev. Biol. 293, 526–539 (2006).

    Article  CAS  Google Scholar 

  9. Piper, K. et al. J. Endocrinol. 181, 11–23 (2004).

    Article  CAS  Google Scholar 

  10. Lumelsky, N. et al. Science 292, 1389–1394 (2001).

    Article  CAS  Google Scholar 

  11. Rajagopal, J. et al. Science 299, 363 (2003).

    PubMed  Google Scholar 

  12. Kubo, A. et al. Development 131, 1651–1662 (2004).

    Article  CAS  Google Scholar 

  13. Yasunaga, M. et al. Nat. Biotechnol. 23, 1542–1550 (2005).

    Article  CAS  Google Scholar 

  14. Kim, S.K. & Melton, D.A. Proc. Natl. Acad. Sci. USA 95, 13036–13041 (1998).

    Article  CAS  Google Scholar 

  15. Wells, J.M. & Melton, D.A. Annu. Rev. Cell Dev. Biol. 15, 393–410 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Madsen, O., Serup, P. Towards cell therapy for diabetes. Nat Biotechnol 24, 1481–1483 (2006). https://doi.org/10.1038/nbt1206-1481

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt1206-1481

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing