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A new path to the cancer epigenome

Nature Biotechnology volume 26, pages 655–656 (2008)Cite this article

A regulator of the spatial organization of chromatin may be a promising target to curb the invasiveness of breast cancer.

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Figure 1: SATB1 (orange), which forms a three-dimensional cage-like network surrounding dense regions of chromatin and is induced during progression of breast cancer, probably tethers multiple gene loci onto its regulatory scaffold and assembles them with chromatin-remodeling complexes (red) and transcription factors.

References

  1. Gal-Yam, E.N., Saito, Y., Egger, G. & Jones, P.A. Annu. Rev. Med. 59, 267–280 (2008).

    Article  CAS  Google Scholar 

  2. Han, H-Y., Russo, J., Kohwi, Y. & Kohwi-Sigematsu, T. Nature 452, 187–193 (2008).

    Article  CAS  Google Scholar 

  3. Cai, S. Lee, C.C. & Kohwi-Shigematsu, T. Nat. Genet. 38, 1278–1288 (2006).

    Article  CAS  Google Scholar 

  4. van't Veer, L.J. et al. Nature 415, 530–536 (2002).

    Article  CAS  Google Scholar 

  5. Dickinson, L.A., Joh, T., Kohwi, Y. & Kohwi-Shigematsu, T. Cell 70, 631–645 (1992).

    Article  CAS  Google Scholar 

  6. Mandell, J.G. & Barbas, C.F. Nucleic Acids Res. 34, W516–523 (2006).

    Article  CAS  Google Scholar 

  7. Nickols, N.G., Jacobs, C.S., Farkas, M.E. & Dervan, P.B. ACS Chem. Biol. 2, 561–571 (2007).

    Article  CAS  Google Scholar 

  8. McManus, M.T. & Sharp, P.A. Nat. Rev. Genet. 3, 737–747 (2002).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Victoria M. Richon is in the Department of Cancer Biology and Therapeutics, Merck Research Laboratories, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA. victoria_richon@merck.com,

    Victoria M Richon

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  1. Victoria M Richon
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Competing interests

V.M.R. is an employee of Merck & Co., Inc. and holds stock in that company.

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Richon, V. A new path to the cancer epigenome. Nat Biotechnol 26, 655–656 (2008). https://doi.org/10.1038/nbt0608-655

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