Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Plugging metal connectors into enzymes

Nature Biotechnology volume 21, pages 631–632 (2003)Cite this article

Turnover of an enzyme is accelerated when the co-reactants are electron vacancies delivered through a gold nanoparticle.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Two routes for construction of gold nanoparticle (Au-NP)–glucose oxidase (GOx) monolayer electrodes.

©Rebecca Henretta

References

  1. Xiao, Y., Patolsky, F., Katz, E., Hainfeld, J.F. & Willner, I. Science 299, 1877–1881 (2003).

    Article  CAS  Google Scholar 

  2. Hecht, H.J., Kalisz, H.M., Hendle, J., Schmid, R.D. & Schomburg, D. J. Mol. Biol. 229, 153–172 (1993).

    Article  CAS  Google Scholar 

  3. Silverman, H.P. & Brake, J.M. US patent no. 3,506,544 (1970).

  4. Degani, Y. & Heller, A. J. Phys. Chem. 91, 1285–1289 (1987).

    Article  CAS  Google Scholar 

  5. Gregg, B.A. & Heller, A. Anal. Chem. 62, 258–263 (1990).

    Article  CAS  Google Scholar 

  6. Heller, A. J. Phys. Chem. 96, 3579–3587 (1992).

    Article  CAS  Google Scholar 

  7. Mao, F., Mano, N. & Heller, A. J. Am. Chem. Soc. 125, 4951–4957 (2003).

    Article  CAS  Google Scholar 

  8. Bourdillon, C., Demaille, C., Moiroux, J. & Saveant, J.M. J. Am. Chem. Soc. 115, 2–10 (1993).

    CAS  Google Scholar 

  9. Bright, H.J. & Porter, D.J.T. in The Enzymes, edn. 3, vol. 12 (ed. Boyer, P.D.) 421–505 (Academic Press, New York, 1975).

    Google Scholar 

  10. Heller, A. Annu. Rev. Biomed. Eng. 1, 153–175 (1999).

    Article  CAS  Google Scholar 

  11. Wagner, J.G. et al. Proc. Nat. Acad. Sci. USA, 95, 6379–6382 (1998).

    Article  CAS  Google Scholar 

  12. Mano, N., Mao, F. & Heller, A. J. Am. Chem. Soc. 124, 12962–12963 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemical Engineering, The University of Texas, Austin, 78712, Texas, USA

    Adam Heller

Authors
  1. Adam Heller
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Heller, A. Plugging metal connectors into enzymes. Nat Biotechnol 21, 631–632 (2003). https://doi.org/10.1038/nbt0603-631

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0603-631

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing