Abstract
The principal tumour-suppressor protein, p53, accumulates in cells in response to DNA damage, oncogene activation and other stresses. It acts as a nuclear transcription factor that transactivates genes involved in apoptosis, cell cycle regulation and numerous other processes. An emerging area of research unravels additional activities of p53 in the cytoplasm, where it triggers apoptosis and inhibits autophagy. These previously unknown functions contribute to the mission of p53 as a tumour suppressor.
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Acknowledgements
Acknowledgments The authors’ own work is supported by NIH and the American Lebanese and Syrian Associated Charities (to D.R.G.) and by Ligue contre le Cancer, INCa, Cancéropole, ANR, ANRS and the Active p53 and Apo-Sys EU networks (to G.K.).
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Green, D., Kroemer, G. Cytoplasmic functions of the tumour suppressor p53. Nature 458, 1127–1130 (2009). https://doi.org/10.1038/nature07986
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DOI: https://doi.org/10.1038/nature07986
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