Abstract
Two new β-class milbemycins from Streptomyces bingchenggensis, named milbemycin β13 and β14, have been isolated and characterized. The producing organism has been deposited at the China General Microbiology Culture Collection Center (Accession No: CGMCC1734). On the basis of detailed spectroscopic analysis and comparison with reported data, their structures were determined to be the hydroxyl derivatives at C-27 of milbemycin β3 and 25-ethylmilbemycin β3, respectively. Milbemycins β13 and β14 possess potent acaricidal and nematocidal activity. The discovery of these two compounds plays an important role in understanding and perfecting the proposed pathways of milbemycins.
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Xiang, WS., Wang, JD., Wang, XJ. et al. Two New β-Class Milbemycins from Streptomyces bingchenggensis: Fermentation, Isolation, Structure Elucidation and Biological Properties. J Antibiot 60, 351–356 (2007). https://doi.org/10.1038/ja.2007.47
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DOI: https://doi.org/10.1038/ja.2007.47
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