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Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families

Genes & Immunity volume 9, pages 364–367 (2008)Cite this article

Abstract

The first genome-wide association study performed in a UK coeliac disease (CD) case-control cohort revealed association with a linkage disequilibrium block containing the KIAA1109/Tenr/IL2/IL21 genes. Also recently, an association with a non-synonymous polymorphism in FcγRIIa (CD32a) was reported in CD with an unusually strong P-value. We aimed to replicate the reported associations with the single nucleotide polymorphisms rs13119723 A>G and rs6822844 G>T in the KIAA1109/Tenr/IL2/IL21 region and rs1801274 G>A in the FcγRIIa gene in a family sample consisting of 325 Swedish/Norwegian families using the robust transmission disequilibrium test. The family sample used in this study included 100 families with two or more children affected by CD and 225 families with one affected child. We could confirm significant association between the polymorphisms rs13119723 A>G and rs6822844 G>T located in the KIAA1109/Tenr/IL2/IL21 region and CD (P-value 0.001 and 0.002, respectively). However, we found no association with the FcγRIIa rs1801274 G>A polymorphism (P-value=0.3). In conclusion, our results support the KIAA1109/Tenr/IL2/IL21 region as a true CD susceptibility region.

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Acknowledgements

We thank all the families participating in the study as well as Britt-Marie Käck and The Celiac Society in Sweden for help with collecting families and blood samples. We also thank the Swegene Genomics and Bioinformatics Core Facility in Göteborg where the significant part of this study (genotyping and statistic analysis) have been done. The work was supported by grants from the Foundation for Strategic Research, the Swedish Medical Research Council (Project no. K98-13X-12568-01A and K2000-27X-12568-03A), the Swedish Research Council (Project no. 2003-5560), the Research Council of Norway, the Gothenburg Medical Society, the European Commission (QLRT-1999-00037), EXTRA funds from the Norwegian Foundation for Health and Rehabilitation, the Swedish Society of Medicine, Frimurare-Barnhusdirektionen, the Foundation of the National Board of Health and Welfare, Sigurd and Elsa Goljes Memory Foundation, the Wilhelm and Martina Lundgren Research Foundation, Lundströms Research Foundation and Häggquist Research Foundation.

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Authors and Affiliations

  1. Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, Gothenburg University, Göteborg, Sweden

    S Adamovic & Å Torinsson Naluai

  2. Centre for Immune Regulation, Institute of Immunology, University of Oslo, Oslo, Norway

    S S Amundsen & L M Sollid

  3. Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway

    B A Lie & L M Sollid

  4. Department of Paediatrics, The Queen Silvia Children's Hospital, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden

    A H Gudjónsdóttir & H Ascher

  5. The Nordic School of Public Health, Göteborg, Sweden

    H Ascher

  6. Department of Paediatrics, Buskerud Central Hospital, Drammen, Norway

    J Ek

  7. Centre for Gastroenterology, Institute of Cell and Molecular Science, Queen Mary University of London, UK

    D A van Heel

  8. Department of Mathematical Sciences, Chalmers University of Technology, Göteborg, Sweden

    S Nilsson

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  1. S Adamovic
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  2. S S Amundsen
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Correspondence to Å Torinsson Naluai.

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Adamovic, S., Amundsen, S., Lie, B. et al. Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families. Genes Immun 9, 364–367 (2008). https://doi.org/10.1038/gene.2008.27

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