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Reversible dasatinib-induced pulmonary arterial hypertension and right ventricle failure in a previously allografted CML patient

Bone Marrow Transplantation volume 43, pages 967–968 (2009)Cite this article

In December 2006, a 48-year-old man presented with a 2-month history of breathlessness and chest pain. He was known to have chronic phase CML since 1997, treated initially with IFN-α. His past history was significant for two allogeneic hematopoietic SCTs (HSCTs) with PBSCs from HLA-mismatched related donors in July 2000 and June 2003, after reduced intensity conditioning with thiotepa 10 mg/kg and CY 100 mg/kg.

CSA and short-course MTX were used for GVHD prophylaxis; rabbit ATG was added to the preparative regimen for second HSCT.

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Authors and Affiliations

  1. Department of Hematology, Santa Croce Hospital, Cuneo, Italy

    D Mattei, N Mordini, D Rapezzi & A Gallamini

  2. Department of Cardiology, Santa Croce Hospital, Cuneo, Italy

    M Feola

  3. Department of Cardiology, University of Torino Medical School, Torino, Italy

    F Orzan

Authors
  1. D Mattei
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  2. M Feola
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  3. F Orzan
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  4. N Mordini
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  5. D Rapezzi
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  6. A Gallamini
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Correspondence to D Mattei.

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Mattei, D., Feola, M., Orzan, F. et al. Reversible dasatinib-induced pulmonary arterial hypertension and right ventricle failure in a previously allografted CML patient. Bone Marrow Transplant 43, 967–968 (2009). https://doi.org/10.1038/bmt.2008.415

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