Nature Genetics
28, 102 - 104 (2001)
doi:10.1038/88797
Asking the age-old questionsPamela L Larsen
Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California, USA. larsen@chem.ucla.edu
Control of lifespan in Caenorhabditis elegans by the DAF-2 insulin-like signaling pathway requires daf-16, which encodes a member of the forkhead family of transcription factors. A new study provides evidence that DAF-2 negatively regulates DAF-16 activity by promoting its retention in the cytoplasm. But, constitutive targeting of DAF-16 to the nucleus is not sufficient to extend lifespan, revealing a new layer of complexity in the genetic control of aging in the nematode.
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