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A role for complement in transmissible spongiform encephalopathies

Nature Medicine volume 7, pages 410–411 (2001)Cite this article

Two recent studies implicate the complement system in prion disease pathogenesis, suggesting that there are multiple, non-exclusive pathways of neuroinvasion (pages 485–487 & 488–492).

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Figure 1: Possible mechanism of complement-mediated uptake of the infectious agent that causes TSEs.

Bob Crimi

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Authors and Affiliations

  1. Laboratory of Virology Istituto Superiore di Sanità, Rome, Italy

    Franco Cardone & Maurizio Pocchiari

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  1. Franco Cardone
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  2. Maurizio Pocchiari
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Cardone, F., Pocchiari, M. A role for complement in transmissible spongiform encephalopathies. Nat Med 7, 410–411 (2001). https://doi.org/10.1038/86469

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