The hair follicle is a major repository for epidermal stem cells. Learning more about the processes that regulate the differentiation of these cells will improve the prospects for skin replacement and treatments for skin cancers.
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Impaired differentiation potential of CD34-positive cells derived from mouse hair follicles after long-term culture
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References
Taylor, G., Lehrer, M.S., Jensen, P.J., Sun, T-T, Laverker, R.M. Involvement of follicular stem cells in forming not only the follicle but also the epidermis. Cell, 102, 451–461 (2000).
Domashenko, A., Gupta, S., Cotsarelis, G. Efficient delivery of transgenes to human hair follicle progenitor cells using topical lipoplex. Nature Biotechnol. 18, 420–423 (2000).
Cotsarelis, G., Sun, T-T., Lavker, R.M. Label retaining cells reside in the bulge of the pilosebaceous unit:implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61,1329–1337 (1990).
Brakebusch, C. et al. Skin and hair follicle integrity is crucially dependent on beta1 integrin expression on keratinocytes. EMBO 19, 3990–4003 (2000).
Akiyama, M., Smith, L.T., Shimizu, H. Changing patterns of localization of putative stem cells in developing human hair follicles. J. Invest. Dermatol. 114, 321–327 (2000).
Lyle, S., Christofidou-Solomidou, M., Liu, Y., Elder, D.E., Albelda, S. & Cotsarelis, G. The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci. 111, 3179–3188 (1998).
Rochat, A., Kobayashi, K. & Barrandon. Y. Location of stem cells of human hair follicles by clonal Analysis. Cell 76, 1063–1073 (1994).
Gat, U., DasGupta, R., Degenstein, L. & Fuchs, E. De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 95, 605–614 (1998).
Chan, E.F., Gat, U., McNiff, J.M., Fuchs, E. A common human skin tumor is caused by activating mutations in beta-catenin. Nature Genet. 21, 410–413 (1999).
Grachtchouk, M. et al. Basal cell carcinomas in mice overexpressing Gli2 in skin. Nature Genet. 3, 216–217 (2000).
Ghali, L., Wongm, S.T. Green, J., Tidman, N. & Quinn, A.G. Gli 1 protein is expressed in basal cell carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin. J. Invest Dermatol. 113, 505–599 (1999).
Bjornson, C.R., Rietze, R.L., Reynolds, B.A., Magli, M.C. & Vescovi, A.L. Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science 283, 534–537 (1999).
Watt, F.M. & Hogan, B.L.M. Out of Eden: stem cells and their niches. Science 287, 1427–1430 (2000).
Oliver, R.F. The induction of hair follicle formation in the adult hooded rat by vibrissa dermal papillae. J.Embryol Exp. Morphol. 23, 219–236 (1970).
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Jahoda, C., Reynolds, A. Skin stem cells – a hairy issue.. Nat Med 6, 1095–1097 (2000). https://doi.org/10.1038/80418
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DOI: https://doi.org/10.1038/80418