Anxiolytic-like and sedative effects of benzodiazepines can be dissociated in mice with a mutant GABAA receptor α1 subunit gene or in wild-type mice by a new benzodiazepine-site ligand.
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References
Horwath, E. & Weissman, M. M. in Comprehensive Textbook of Psychiatry Vol. 1, 7th Ed. (eds. Sadock, B. J. & Sadock, V. A.) 1444–1450 (Lippincott, Williams and Wilkins, New York, 2000).
Ballenger, J. C. in Comprehensive Textbook of Psychiatry Vol. 1, 7th Ed. (eds. Sadock, B. J. & Sadock, V. A.) 2317–2323 (Lippincott, Williams and Wilkins, New York, 2000).
Rudolph, U. et al. Nature 401, 796–800 (1999).
McKernan, R. et al. Nat. Neurosci. 3, 587–592 (2000).
Sigel, E. & Buhr, A. Trends Pharmacol. Sci. 18, 425–429 (1997).
Sieghart, W. Pharmacol. Rev. 47, 181–234 (1995).
Wieland, H. A., Lüddens, H. & Seeburg, P. H. J. Biol. Chem. 267, 1426–1429 (1992).
Benson, J. A., Löw, K., Keist, R., Mohler, H. & Rudolph, U. FEBS Lett. 431, 400–404 (1998).
Kleingoor, C., Wieland, H. A., Korpi, E. R., Seeburg, P. H. & Kettenmann, H. Neuroreport 4, 187–190 (1993).
Fritschy, J. M. & Mohler, H. J. Comp. Neurol. 359, 154–194 (1995).
Lister, R. G. Pharmacol. Ther. 46, 321–340 (1990).
Crabbe, J. C., Wahlsten, D. & Dudek, B. C. Science 284, 1670–1672 (1999).
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Tecott, L. Designer genes and anti-anxiety drugs. Nat Neurosci 3, 529–530 (2000). https://doi.org/10.1038/75692
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DOI: https://doi.org/10.1038/75692
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