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AMPA receptors jump the synaptic cleft

Nature Neuroscience volume 3, pages 527–529 (2000)Cite this article

Satake et al. show that glutamate release in the cerebellum causes heterosynaptic depression of GABA release and that AMPA receptors act presynaptically to mediate this phenomenon.

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Figure 1: Climbing fiber activation causes glutamate spread onto presynaptic AMPA receptors on basket cell terminals.

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Authors and Affiliations

  1. Departments of Cellular and Molecular Pharmacology, and Physiology, University of California, San Francisco, 94143–0450, California, USA

    Roger A. Nicoll, Matthew Frerking & Dietmar Schmitz

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  1. Roger A. Nicoll
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  2. Matthew Frerking
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  3. Dietmar Schmitz
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Nicoll, R., Frerking, M. & Schmitz, D. AMPA receptors jump the synaptic cleft. Nat Neurosci 3, 527–529 (2000). https://doi.org/10.1038/75689

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