Nature 380, 152 - 154 (14 March 1996); doi:10.1038/380152a0

A comprehensive genetic map of the human genome based on 5,264 microsatellites

Colette Dib^*, Sabine Fauré^*, Cécile Fizames^*, Delphine Samson^*, Nathalie Drouot^*, Alain Vignal^*, Philippe Millasseau^*, Sophie Marc^*, Jamile Kazan^*, Eric Seboun^*, Mark Lathrop^†, Gabor Gyapay^*, Jean Morissette^*‡ & Jean Weissenbach^*§

^*Génethon and CNRS URA 1922, 1 rue de I'Internationale, 91000 Evry, France
^†INSERM U358, Hôpital Saint-Louis, Paris, France
^‡Centre de Recherche du Centre Hospitalier de I'Université Laval, Québec G1V 4G2, Canada
^§To whom correspondence should be addressed

THE great increase in successful linkage studies in a number of higher eukaryotes during recent years has essentially resulted from major improvements in reference genetic linkage maps¹⁻⁶, which at present consist of short tandem repeat polymorphisms of simple sequences or microsatellites^7,8. We report here the last version of the Généthon human linkage map⁶. This map consists of 5,264 short tandem (AC/TG)n repeat polymorphisms with a mean heterozygosity of 70%. The map spans a sex-averaged genetic distance of 3,699 cM and comprises 2,335 positions, of which 2,032 could be ordered with an odds ratio of at least 1,000:1 against alternative orders. The average interval size is 1.6 cM; 59% of the map is covered by intervals of 2 cM at most and 1% remains in intervals above 10 cM.

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