Nature 373, 123 - 126 (12 January 1995); doi:10.1038/373123a0

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

David D. Ho, Avidan U. Neumann^*†, Alan S. Perelson^†, Wen Chen, John M. Leonard^‡ & Martin Markowitz

Aaron Diamond AIDS Research Center, NYU School of Medicine, 455 First Avenue, New York, New York 10016, USA
^*Santa Fe Institute, Santa Fe, New Mexico 87501, USA
^†Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
^‡ Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064, USA

Treatment of infected patients with ABT-538, an inhibitor of the protease of human immuno-deficiency virus type 1 (HIV-1), causes plasma HIV-1 levels to decrease exponentially (mean half-life, 2.1 Â0.4 days) and CD4 lymphocyte counts to rise substantially. Minimum estimates of HIV-1 production and clearance and of CD4 lymphocyte turnover indicate that replication of HIV-1 in vivo is continuous and highly productive, driving the rapid turnover of CD4 lymphocytes.

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