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Defective interfering particles with covalently linked [±]RNA induce interferon

Nature volume 266, pages 815–819 (1977)Cite this article

Abstract

Defective interfering (DI) particles of vesicular stomatitis virus which contain covalently linked complementary [+]message and [−]anti-message RNA as a single-stranded ribonucleoprotein complex within the particle, are extremely efficient inducers of interferon. A single particle can induce a quantum yield of interferon. A single molecule of double-stranded RNA presumed to form, at least in part, on entry into the cell is thought to induce interferon synthesis. Conventional [−]RNA DI particles with the same polypeptide composition as [±]RNA DI particles fail to induce interferon.

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Authors and Affiliations

  1. Microbiology Section, U-44, University of Connecticut, Storrs, Connecticut, 06268

    Philip I. Marcus & Margaret J. Sekellick

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  1. Philip I. Marcus
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  2. Margaret J. Sekellick
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Marcus, P., Sekellick, M. Defective interfering particles with covalently linked [±]RNA induce interferon. Nature 266, 815–819 (1977). https://doi.org/10.1038/266815a0

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