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Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitis

Nature volume 251, pages 547–548 (1974)Cite this article

Abstract

THE cytotoxic activity1,2 of immune thymus-derived lymphocytes (T cells) for 51Cr-labelled fibroblasts, or macrophages infected with lymphocytic choriomeningitis (LCM) virus is restricted by the H-2 gene complex3,4. Specific lysis of LCM-infected monolayer cultures occurs only when targets and overlaying, sensitised T cells share at least one set of H-2 antigenic specificities.

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References

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Authors and Affiliations

  1. Department of Microbiology, The John Curtin School of Medical Research, Canberra, A.C.T., Australia

    ROLF M. ZINKERNAGEL & PETER C. DOHERTY

Authors
  1. ROLF M. ZINKERNAGEL
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  2. PETER C. DOHERTY
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ZINKERNAGEL, R., DOHERTY, P. Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitis. Nature 251, 547–548 (1974). https://doi.org/10.1038/251547a0

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  • DOI: https://doi.org/10.1038/251547a0

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