Abstract
A partial impairment of GABAA receptor function in mice causes behavioral changes that resemble generalized anxiety disorder in humans. But understanding the genetic control of the 'neurotic' personality is still a challenge.
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References
Crestani, F., Loez, M., Baer, K., Essrich, C., Benke, D., Laurent, J.P., Belzung, C., Fristchy, J.-M., Luscher, B. & Mohler, H. Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues. Nature Neurosci. 2, 833–839 (1999).
Blanchard, R. J., Griebel, G., Henrie, J. A. & Blanchard, D. C. Differentiation of anxiolytic and panicolytic drugs by effects on rat and mouse defense test batteries. Neurosci. Biobehav. Rev. 21, 783–789 (1997).
Gray, J. A. & McNaughton, N. in Perspectives on Anxiety, Panic and Fear (ed. Hope, D.A.) 61–134 (University of Nebraska Press, Nebraska, 1998).
Gray, J.A. & McNaughton, N. in The neuropsychology of anxiety: an enquiry into the functions of the septo-hippocampal system 2nd edition (Oxford University Press, Oxford, in the press).
Graeff, F.G. Neuroanatomy and neurotransmitter regulation of defensive behaviors and related emotions in mammals. Braz. J. Med. Biol. Res. 27, 811–829 (1994).
Davis, M. The role of the amygdala in fear-potentiated startle: implications for animal models of anxiety. Trends in Pharmacological Science 13 35–41, (1992).
Andrews, G., Stewart, G., Morris-Yates, A., Holt, P. & Henderson, S. Evidence for a general neurotic syndrome. Br. J. Psychiatr. 157, 6–12 (1990).
Anagnostaras, S. G., Craske, M. G. & Fanselow, M. S. Anxiety: at the intersection of genes and experience. Nature Neurosci. 2, 780–782 (1999).
McNaughton, N. Cognitive dysfunction resulting from hippocampal hyperactivity—a possible cause of anxiety disorder? Pharmacol. Biochem. Behav. 56, 603–611 (1997).
Pan, W. X. & McNaughton, N. The medial supramammillary nucleus, spatial learning and the frequency of hippocampal theta activity. Brain Res. 764, 101–108 (1997).
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McNaughton, N. A gene promotes anxiety in mice—and also in scientists. Nat Med 5, 1131–1132 (1999). https://doi.org/10.1038/13455
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DOI: https://doi.org/10.1038/13455
