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Unraveling hepatitis B virus infection of mice and men (and woodchucks and ducks)

Abstract

The development of liver diseases in patients suffering from chronic hepatitis B infection is determined by the nature of the host immune response. Several factors have made this immune response difficult to study, but recently developed animal models will help clear the way.

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Figure 1: Humoral- and cellular-mediated immunity during acute hepatitis B virus (HBV) infection leading to viral clearance.

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Menne, S., Tennant, B. Unraveling hepatitis B virus infection of mice and men (and woodchucks and ducks). Nat Med 5, 1125–1126 (1999). https://doi.org/10.1038/13445

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