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Successful related umbilical cord blood transplantation for graft failure following T cell-depleted non-identical bone marrow transplantation in a child with major histocompatibility complex class II deficiency

Bone Marrow Transplantation volume 24, pages 437–440 (1999)Cite this article

Abstract

Major histocompatibility complex (MHC) class II deficiency is a rare form of primary combined immunodeficiency that can only be corrected by stem cell transplantation. We report a 4½-year-old girl with MHC class II deficiency who underwent a related CBT due to graft failure following T cell-depleted non-identical BMT. The patient is alive and well 2 years after the second transplant. A sustained hematopoietic engraftment and a progressive immune recovery have been detected. We conclude that cord blood may be an effective source of hematopoietic stem cells for patients with immuno- deficiency disorders including diseases with a high rate of graft failure.

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Authors and Affiliations

  1. Department of Hematology/Oncology and Bone Marrow Transplant Unit, Hospital de Pediatría ‘Prof Dr Juan P Garrahan’, Buenos Aires, Argentina

    M Bonduel, C Figueroa & FSackmann Muriel

  2. Transfusion Medicine Service, Hospital de Pediatría ‘Prof Dr Juan P Garrahan’, Buenos Aires, Argentina

    A del Pozo & S Delfino

  3. Department of Immunology, Hospital de Pediatría ‘Prof Dr Juan P Garrahan’, Buenos Aires, Argentina

    M Zelazko & J Rossi

  4. Department of Radiotherapy, Hospital de Pediatría ‘Prof Dr Juan P Garrahan’, Buenos Aires, Argentina

    E Raslawski

Authors
  1. M Bonduel
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  2. A del Pozo
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  3. M Zelazko
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  4. E Raslawski
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  5. S Delfino
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  6. J Rossi
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  7. C Figueroa
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  8. FSackmann Muriel
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Bonduel, M., del Pozo, A., Zelazko, M. et al. Successful related umbilical cord blood transplantation for graft failure following T cell-depleted non-identical bone marrow transplantation in a child with major histocompatibility complex class II deficiency. Bone Marrow Transplant 24, 437–440 (1999). https://doi.org/10.1038/sj.bmt.1701915

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  • DOI: https://doi.org/10.1038/sj.bmt.1701915

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