Abstract
Chromosomal abnormalities in tumours were recognized at the end of the last century but their significance has only recently become clear. Distinct translocations in leukaemias and in solid tumours lead to the activation of protooncogene products or, more commonly, creation of tumour-specific fusion proteins. The proteins in both categories are often transcription factors and thus disruption of transcriptional control plays a major role in the aetiology of cancer. Fusion proteins formed after chromosomal translocations are common in a range of tumour types; these are unique tumour antigens and are therefore potential targets for therapy design.
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References
Boveri, T. Zur Frage der Entstehung Maligner Tumoren (Fischer, Jena, Germany, 1914).
Rabbitts, T. H. & Boehm, T. Adv. Immun. 50, 119–146 (1991).
Malcolm, S. et al. Proc. natn. Acad. Sci. U.S.A. 79, 4957–4961 (1982).
Blackwood, E. M. & Eisenman, R. N. Science 251, 1211–1217 (1991).
Prendergast, G. C., Lawe, D. & Ziff, E. Cell 65, 395–407 (1991).
Ayer, D. E., Kretzner, L. & Eisenman, R. N. Cell 72, 211–222 (1993).
Zervos, A. S., Gyuris, J. & Brent, R. Cell 72, 223–232 (1993).
Amati, B. et al. Cell 72, 233–245 (1993).
Strasser, A. et al. Proc. natn. Acad. Sci. U.S.A. 88, 8661–8665 (1991).
Sentman, C. L., Shutter, J. R., Hockenberry, D., Kanagawa, O. & Korsmeyer, S. J. Cell 67, 879–888 (1991).
Strasser, A., Harris, A. W. & Cory, S. Cell 67, 889–899 (1991).
Hockenberry, D. M., Oitval, Z. N., Yin, X.-M., Milliman, C. L. & Korsmeyer, S. J. Cell 75, 241–251 (1993).
Kane, D. J. et al. Science 262, 1274–1277 (1993).
Korsmeyer, S. J., Shutter, J. R., Veis, D. J., Merry, D. E. & Oltvai, Z. N. Sem. Cancer Biol. 4, 327–332 (1993).
Dube, I. D. et al. Blood 78, 2996–3003 (1991).
Hatano, M., Roberts, C. W. M., Minden, M., Crist, W. M. & Korsmeyer, S. J. Science 253, 79–82 (1991).
Kennedy, M. A. et al. Proc. natn. Acad. Sci. U.S.A. 88, 8900–8904 (1991).
Lu, M., Gong, Z., Shen, W. & Ho, A. D. EMBO J. 10, 2905–2910 (1991).
Dear, T. N., Sanchez-Garcia, I. & Rabbitts, T. H. Proc. natn. Acad. Sci. U.S.A. 90, 4431–4435 (1993).
Baer, R. Sem. Cancer Biol. 4, 341–347 (1993).
Hsu, H.-L., Cheng, J.-T., Chen, Q. & Baer, R. Molec. cell. Biol. 11, 3037–3042 (1991).
Sanchez-Garcia, I. & Rabbitts, T. H. Sem. Cancer Biol. 4, 349–358 (1993).
Boehm, T., Foroni, L., Kennedy, M. & Rabbitts, T. H. Oncogene 5, 1103–1105 (1990).
Perez-Alvarado, G. C. et al. Nature struct. Biol. 1, 388–398 (1994).
Rabbitts, T. H. & Boehm, T. Nature 346, 418 (1990).
Valge-Archer, V. E. et al. Proc. natn. Acad. Sci. U.S.A. 91, 8617–8621 (1994).
Wadman, I. et al. EMBO J. 3, 4831–4839 (1994).
Warren, A. J. et al. Cell 78, 45–58 (1994).
Nowell, P. C. & Hungerford, D. A. Science 132, 1497 (1960).
Bartram, C. R. et al. Nature 306, 277–280 (1983).
de Klein, A. et al. Blood 68, 1369–1375 (1986).
Kamps, M. P., Murre, C., Sun, X.-H. & Baltimore, D. Cell 60, 547–555 (1990).
Nourse, J. et al. Cell 60, 535–545 (1990).
Ohki, M. Sem. Cancer Biol. 4, 369–376 (1993).
Laabi, Y. et al. EMRO J. 11, 3897–3904 (1992).
Golub, T. R., Barker, G. F., Lovett, M. & Gilliland, D. G. Cell 77, 307–316 (1994).
Morris, S. W. et al. Science 263, 1281–1284 (1994).
Mizuno, K. et al. Oncogene 9, 1605–1612 (1994).
Gillard, E. F. & Solomon, E. Sem. Cancer Biol. 4, 359–368 (1993).
Chen, Z. et al. EMBO J. 12, 1161–1167 (1993).
van Dijk, M. A., Voorhoeve, P. M. & Murre, C. Proc. natn. Acad. Sci. U.S.A. 90, 6061–6065 (1993).
Hunger, S. P., Ohyashiki, K., Toyama, K. & Cleary, M. L. Genes Dev. 6, 1608–1620 (1992).
Inaba, T. et al. Science 257, 531–534 (1992).
Djabali, M. et al. Nature Genet. 2, 113–118 (1992).
Gu, Y. et al. Cell 71, 701–708 (1992).
Tkachuk, D. C., Kohler, S. & Cleary, M. L. Cell 71, 691–700 (1992).
Corral, J. et al. Proc. natn. Acad. Sci. U.S.A. 90, 8538–8542 (1993).
Pierotti, M. A. et al. Proc. natn. Acad. Sci. U.S.A. 89, 1616–1620 (1992).
Delattre, O. et al. Nature 359, 162–165 (1992).
Crozat, A., Aman, P., Mandahl, N. & Ron, D. Nature 363, 640–644 (1993).
Rabbitts, T. H., Forster, A., Larson, R. & Nathan, P. Nature Genet. 4, 175–180 (1993).
Barr, F. G. et al. Nature Genet. 3, 113–117 (1993).
Galili, N. et al. Nature Genet. 5, 230–235 (1993).
Clark, J. et al. Nature Genet. 7, 502–5087 (1994).
Ben-David, Y., Giddens, E. B., Letwin, K. & Bernstein, A. Genes Dev. 5, 908–918 (1991).
Zucman, J. et al. EMBO J. 12, 4481–4487 (1993).
May, W. A. et al. Proc. natn. Acad. Sci. USA. 90, 5752–5756 (1993).
Sorensen, P. H. B. et al. Nature Genet. 6, 146–151 (1994).
Zucman, J. et al. Nature Genet. 4, 341–345 (1993).
Mulligan, L. M. et al. Nature 363, 458–460 (1993).
Shimizu, K. et al. Proc. natn. Acad. Sci. U.S.A. 90, 10280–10284 (1993).
Ron, D. & Habener, J. F. Genes Dev. 6, 439–453 (1992).
Sanchez-Garcia, I. & Rabbins, T. H. Proc. natn. Acad. Sci. U.S.A. 91, 7869–7873 (1994).
Maulbecker, C. C. & Gruss, P. EMBO J. 12, 2361–2367 (1993).
Rowley, J. D. Genes Chrom. Cancer 5, 264–266 (1992).
Shima, E. A. et al. Proc. natn. Acad. Sci. U.S.A. 83, 3439–3443 (1986).
Rimokh, R. et al. Genes Chrom. Cancer 3, 24–36 (1991).
Mellentin, J. D., Smith, S. D. & Cleary, M. L. Cell 58, 77–83 (1989).
Kerckaert, J.-P. et al. Nature Genet. 5, 66–70 (1993).
Ye, B. H. et al. Science 262, 747–750 (1993).
Gauwerky, C. E. & Croce, C. M. Sem. Cancer Biol. 4, 333–340 (1993).
Mengle-Gaw, L. et al. EMBO J. 6, 2273–2280 (1987).
Neri, A. et al. Cell 67, 1075–1087 (1991).
Ohno, H., Takimoto, G. & McKeithan, T. W. Cell 60, 991–997 (1990).
Wulczyn, F. G., Naumann, M. & Scheidereit, C. Nature 358, 597–599 (1992).
Kerr, L. D. et al. Genes Dev. 6, 2352–2363 (1992).
Grimaldi, J. C. & Meeker, T. C. Blood 73, 2081–2085 (1989).
Meeker, T. C., Hardy, D., Willman, C., Hogan, T. & Abrams, J. Blood 76, 285–289 (1990).
Ellisen, L. W. et al. Cell 66, 649–661 (1991).
Burnett, R. C. et al. Genes Chrom. Cancer 3, 461–467 (1991).
Tycko, B., Smith, S. D. & Sklar, J. J. exp. Med. 174, 867–873 (1991).
Fisch, P., Forster, A., Sherrington, P. D., Dyer, M. J. S. & Rabbitts, T. H. Oncogene 8, 3271–3276 (1993).
Stern, M.-H. et al. Oncogene 8, 2475–2483 (1993).
Baer, R., Chen, K.-C., Smith, S. D. & Rabbitts, T. H. Cell 43, 705–713 (1985).
Denny, C. T. et al. Nature 320, 549–551 (1986).
de Klein, A. et al. Nature 300, 765–767 (1982).
Nakamura, T. et al. Proc. natn. Acad. Sci. U.S.A. 90, 4631–4635 (1993).
lida, S. et al. Oncogene 8, 3085–3092 (1993).
Yamamoto, K. et al. Oncogene 8, 2617–2625 (1993).
Bernard, O. A., Mauchauffe, M., Mecucci, C., Van Den Berghe, H. & Berger, R. Oncogene 9, 1039–1045 (1994).
Prasad, R. et al. Cancer Res. 53, 5624–5628 (1993).
Prasad, R. et al. Proc. natn. Acad. Sci. U.S.A. 91, 8107–8111 (1994).
Mitani, K. et al. EMBO J. 13, 504–510 (1994).
Nucifora, G., Begy, C. R., Erickson, P., Drabkin, H. A. & Rowley, J. D. Proc. natn. Acad. Sci. U.S.A. 90, 7784–7788 (1993).
von Lindern, M. et al. Molec. cell. Biol. 12, 1687–1697 (1992).
von Lindern, M., Breems, D., van Baal, S., Adriaansen, H. & Grosveld, G. Genes Chrom. Cancer 5, 227–234 (1992).
Lu, D. et al. Oncogene 6, 1235–1241 (1991).
Liu, P. et al. Science 261, 1041–1044 (1993).
Ichikawa, H., Shimizu, K., Hayashi, Y. & Ohki, M. Cancer Res. 54, 2865–2868 (1994).
Panagopoulos, I. et al. Genes Chrom. Cancer (in the press).
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Rabbitts, T. Chromosomal translocations in human cancer. Nature 372, 143–149 (1994). https://doi.org/10.1038/372143a0
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DOI: https://doi.org/10.1038/372143a0
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