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Lifespan of human lymphocyte subsets defined by CD45 isoforms

Nature volume 360, pages 264–265 (1992)Cite this article

Abstract

THE lifespan of thymic-derived or T lymphocytes is of particular interest because of their central role in immunological memory. Is the recall of a vaccination or early infection, which may be demonstrated clinically up to 50 years after antigen exposure1, retained by a long-lived cell, or by its progeny? Using the observation that T lymphocyte expression of isoforms of CD45 corresponds with their ability to respond to recall antigens, we have investigated the lifespan of both CD45RO (the subset containing responders, or 'memory' cells) and CD45RA (the unresponsive, or 'naive' subset) lymphocytes in a group of patients after radiotherapy. Here we report rapid loss of unstable chromosomes from the CD45RO but not the CD45RA pool. Immunological memory therefore apparently resides in a population with a more rapid rate of division. Differing survival curves for the two subsets are best described by a model in which there is also reversion in vivo from the CD45RO to the CD45RA phenotype. Expression of CD45RO in T cells may therefore be reversible.

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Authors and Affiliations

  1. Human Tumour Immunology Group, University College and Middlesex School of Medicine, 91 Riding House Street, London, W1P 8BT, UK

    Colin A. Michie & Peter C. L. Beverley

  2. Department of Zoology, University of Oxford, Oxford, OX13PS, UK

    Angela McLean

  3. Department of Oncology and Radiotherapy, Churchill Hospital, Oxford, OX3 7L J, UK

    Christopher Alcock

Authors
  1. Colin A. Michie
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  2. Angela McLean
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  3. Christopher Alcock
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  4. Peter C. L. Beverley
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Michie, C., McLean, A., Alcock, C. et al. Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature 360, 264–265 (1992). https://doi.org/10.1038/360264a0

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