Abstract
Antigen-specific cell contacts in the immune system are strengthened by antigen-nonspecific interactions, mediated in part by lymphocyte-function associated (LFA) antigens1,2. The LFA-1 antigen is widely expressed on cells of haematopoietic origin and is a major receptor of T cells, B cells and granulocytes3. LFA-1 mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by natural killer cells and granulocytes. Recently, ICAM-1 (intercellular adhesion molecule-1) has been defined as a ligand for LFA-14–6. Monoclonal antibodies to ICAM-1 block T lymphocyte adhesion to fibroblasts and endothelial cells and disrupt the interaction between cytotoxic T cells and target cells. In addition, purified ICAM-1 reconstituted into artificial membranes binds LFA-1+ cells6. ICAM-1 is found on leukocytes, fibroblasts, epithelial cells and endothelial cells and its expression is regulated by inflammatory cytokines. LFA-1 has been placed in the integrin family of cell surface receptors by virtue of the high sequence similarity between the LFA-1 and integrin β chains7,8. The adhesion ligands of the integrin family are gly-coproteins bearing the Arg-Gly-Asp (RGD) sequence motif, for example, fibronectin, fibrinogen, vitronectin and von Willebrand factor9. Here we show that a complementary DNA clone ICAM-1 contains no RGD motifs, but instead is homologous to the neural cell adhesion molecule NCAM10,11.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Springer, T. A., Dustin, M. L., Kishimoto, T. K. & Marlin, S. D. A. Rev. Immun. 5, 223–252 (1987).
Anderson, D. C. & Springer, T. A. Rev. Med. 5, 175–194 (1987).
Rothlein, R. & Springer, T. A. J. exp. Med. 163, 1132–1149 (1987).
Rothlein, R., Dustin, M. L., Marlin, S. D. & Springer, T. A. J. Immun. 137, 1270–1275 (1986).
Dustin, M. L., Rothlein, R., Bahn, A. K., Dinarello, C. A. & Springer T. A. J. Immun. 137 245–254 (1986).
Marlin, S. D. & Springer, T. A. Cell 51, 813–819 (1987).
Kishimoto, T. K., O'Conner, K., Lee, A., Roberts, T. M. & Springer, T. A. Cell 48, 681–690 (1987).
Hynes, R. O. Cell 48, 549–554 (1987).
Ruoslahti, E. & Pierschbacher, M. D. Cell 44, 517–518 (1987).
Cunningham, B. A. et al. Science 236, 799–806 (1987).
Barthels, D. et al. EMBO J. 6, 907–914 (1987).
Leukocyte Typing III. White Cell Differentiation Antigens (eds McMichael, A. J. et al.) (Oxford University Press, 1987).
Seed, B. & Aruffo, A. Proc. natn. Acad. Sci. U.S.A 84, 3365–3369 (1987).
Aruffo, A. & Seed, B. Proc. natn. Acad. Sci. U.S.A. 84, 8573–8577 (1987).
von Heijne, G. Nucleic Acids Res. 14, 4683–4690 (1986).
Dayhoff, M. O., Barker, W. C. & Hunt, L. T. Meth. Enzym. 91, 524–545 (1983).
Williams, A. F. Immun. Today 8, 298–303 (1987).
Arguint, M. et al. Proc. natn. Acad. Sci. U.S.A. 84, 600–604 (1987).
Beauchemin, N., Benchimol, S., Cournoyer, D., Fuks, A. & Stanners, C. P. Molec. cell. Biol. 7, 3221–3230 (1987).
Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Simmons, D., Makgoba, M. & Seed, B. ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. Nature 331, 624–627 (1988). https://doi.org/10.1038/331624a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/331624a0
This article is cited by
-
Comprehensive genotyping analysis of single nucleotide polymorphisms responsible for beef marbling in Japanese Black cattle
BMC Genomic Data (2024)
-
Anti inflammatory effect of asiaticoside on human umbilical vein endothelial cells induced by ox-LDL
Cytotechnology (2018)
-
Homeostatic and innate immune responses: role of the transmembrane glycoprotein CD98
Cellular and Molecular Life Sciences (2012)
-
Intercellular adhesion molecule-1 (ICAM-1) gene polymorphism and endometriosis in northern Iran
Archives of Gynecology and Obstetrics (2011)
-
Strategies for treating liver metastasis from gastric cancer
Surgery Today (2010)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.