The polymerase chain reaction can synthesize millions of copies of a specific DNA sequence in a brief in vitro reaction. (Thermostable DNA polymerase from Thermus aquaticus improves the technique.)
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References
Mullis, K.B. & Faloona, F.A. Meth Enzym. 155, 335–350 (1987).
Saiki, R.K. et al. Science 230, 1350–1354 (1985).
Scharf, S.J., Horn, G.T. & Erlich, H.A. Science 233, 1076–1078 (1986).
Saiki R.K. et al. Science, 239, 487–491 (1988).
Saiki, R.K., Bugwan, T., Horn, G., Mullis, K. & Erlich, H.A. Nature 324, 163–166 (1986).
Embury, S. et al. New Engl.J. Med. 316, 656–661 (1987).
Kogan, S.C., Doherty, M. & Gitschier, J. New Engl J. Med. 317, 985–990 (1987).
Kwok, S. et al. J. Virol. 61, 1690–1694 (1987).
Ou, C.-Y. et al. Science, 239, 295–297 (1988).
Kwok, S. et al. (in preparation).
Duggan, D. et al. Blood (in the press).
Shibata, D., Martin, W.J. & Arnheim, N. J. exp. Med. 167, 225–230 (1988).
Farr, C.J., Saiki, R.K., Erlich, H.A., McCormick, S. & Marshall C.J. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).
Bos, J. et al. Nature 327, 293–297 (1987).
Horn, G.T., Bugawan, T.L., Long, C.M. & Erlich, H.A. Proc. natn. Acad. Sci. U.S.A. (in the press).
Higuchi, R., von Beroldingen, C.H., Sensabaugh, G. & Erlich, H.A. (in preparation).
Wrischnik, L.A. et al. Nucleic Acids Res. 15, 529–542 (1987).
Wong, C. et al. Nature 330, 384–386 (1987).
Mack, D.H. & Sninsky, J.J. (in preparation).
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Erlich, H., Gelfand, D. & Saiki, R. Specific DNA amplification. Nature 331, 461–462 (1988). https://doi.org/10.1038/331461a0
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DOI: https://doi.org/10.1038/331461a0
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